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A large amount of sperm donors pass through genetic cancer, causing mutations to 10 offspring.

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Suddenly genetically causing cancer in sperm europe Through Dasan Clinic. Ten of those children have already been diagnosed. cancerIncluding leukemia and non -lymphoma.

When a child was diagnosed with cancer, two separate families contacted Dasan Clinic, and this incident was revealed. Genetic tests confirm that children have rare mutations in the TP53 genes, creating proteins that suppress tumor growth.

In addition, the donor also has the same mutation, which has the same mutation related to Li-Fraumeni syndrome.

In the subsequent exams, 67 children born in the sperm of this donor are found and spread to 46 families in eight European countries. Of these, 23 children have been found to have mutations, and ten have already developed cancer. All of the influenced children were born between 2008 and 2015, indicating that the donor’s sperm was used without centralized supervision for several years.

Children with mutations of TP53 are now undergoing strict medical surveillance, including regular ultrasound screening of chest and abdomen when reaching the whole body and brain MRI, adults and frequent clinical examinations. Doctors advise on how to imagine-based imaging, such as breast angiography or PET-CT scan, can worsen the condition of patients with Li-fraumeni syndrome.

The donor moved the mutant mosaic

The mutation was not recognized as a cancer in 2008, so it was not found in everyday donor screening. Only a part of the donor’s sperm had mutations, suggesting a state called a genital mosa. Here, genetic mutations exist in reproductive cells, but not in the rest of the body.

This means that the donor can unconsciously pass a serious hereditary disease. Similar cases cause skin tumors and pigment changes, including donors that have previously passed through mutations that have previously caused nerve fibrosis types 1.

In accordance with the internal policy, sperm banks that distribute the sperm of the donor restrict each donor to 75 families. Even after the discovery of mutations, the bank did not disclose the number of children born from the donor, and raised concerns that more children could be affected but still unnecessary and understood.

Lack of international regulation meets risks

Regulatory gaps between countries worsen problems. France limits each donor to 10 Germany, 15 in Germany, and 10-12 families in the UK. However, in many other countries, such limitations do not exist, personal sperm banks are often operated by their own policy, and dozens of children can be born from a single donor. Without adjusted international systems, many families do not know the shared genetic risk.

This case emphasizes the potential risks of sperm donations and lack of regulatory protection measures. In addition to the extensive risk of genetic diseases, there is no supervisor, so it is difficult to ensure medical monitoring of influenced children and seeking life.

The French medical authorities recommend choosing fertility treatment in countries where donations are strictly supervised by public health authorities. In France, the donation must be anonymous and voluntary (unpaid), and a strict medical checkup of both donors and recipients. Exports and imports of reproductive cells require special approval of National Bioethics Agency.

Israel: There is no law on the donor limit

Israel currently lacks binding legislation to limit the number of sperm donors. The guidelines issued by the Ministry of Health and the individual sperm bank act as the only framework. Each bank sets its own limit to reduce the risk of unintended family relationships.

4 View gallery

d"Eran Altmand"Eran Altman

Dr. Erian Altman

(Photo: Shlomi YOSEF))

Dr. Eran Altman, head of the sperm bank at the Rabin Medical Center, told Ynet earlier this year: “The key question is not the number of samples provided by the donor, but the number of a single donor from a single donor. He added that he had warned of the long -term government activities.

For example, sperm banks of Tel Aviv Sourasky Medical Center limit donors to 10 families. In contrast, many Israeli women switch to overseas banks (sometimes through local agents).

Nevertheless, Israeli experts pay attention to About using imported sperm. Dr. YIGAL MADJAR, director of Assuta SUPERM BANK, said, “statistically risk of genetic problems is higher in foreign sperm.” Foreign donors can have 200 to 300 children worldwide. It is almost impossible to track all of the genetic disease surfaces. “

In contrast, Altman pointed out that Israeli donors have been identified in the Ministry of Health, signed monopoly contracts, and donations to various local banks, reducing the risk of duplicate or fraud.

4 View gallery

d"R. YIGAL MADAGERd"R. YIGAL MADAGER

Ph.D. for Madjar

(Photo: Oded Karni))

The Ministry of Health has previously announced plans to capture each donor in 10 households, but several individual legislation was submitted to the effect, but the law was not passed.

This case remains rare, but experts like Dr. Madjar warn that it could happen again if strict international regulations were not adopted. They legally capture the number of children per donor, which requires entirely transparency and adjustment between the countries, and ensures all of the family’s medical follow -up measures.





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