Researchers at the University of Oregon discovered molecules produced by yeast on human skin and showed strong antibacterial characteristics of pathogens in the United States, which are in charge of 500,000 hospitals every year.
It is a unique approach to solve the increasing problem of antibiotic resistant bacteria. Due to the global threat of drug resistance infection, the fungus living in human skin is a resource for identifying new antibiotics.
Explain Published As of last month, in biology, the general skin fungus is producing fatty acids that selectively remove stabilizers by absorbing oil and fat in human skin.
One out of three is a staphylococcus aurreus, which is harmless to the nose, but bacteria are a risk of serious infections when open wounds, wear and cut opportunities are given. They are the main causes of skin and soft tissue infections known as staphylic infections.
Staphylococcus Aureus is also a favorite hospital superberg, which is now resistant to antibiotics, increases the need for new medicines.
Kowalski said that there are many studies that identify a new antibiotic structure. “But our fun and interesting thing is that we are well known and people have identified what they have studied before.”
This compound is not toxic under normal laboratory conditions, but it can be powerful under the condition of replicating the acidic environment of healthy skin. Kowalski said, “I think this is why we missed this kind of antibacterial mechanism.
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Kowalski said that humans host a huge microbial arrangement known as a microbial cluster, but we rarely know about contributions to mold and human health. Skin microorganisms have a special interest in her. Other body parts have many other molds, but the skin is dominantly colonized by one type known as Malassezia.
Malassezia may be associated with the case of dandruff and eczema, but it is relatively harmless and is considered a normal part of the skin plant. The yeast evolves to live in the mammalian skin and is decomposed by the skin because it cannot make fatty acids without oil and fat.
Kowalski said that despite the richness of Malassezia discovered on us, they remained in research.
“Skin is a system that is parallel to what happens in the intestine, and is really well studied.” She said in the media release. “We know that the intestinal microbial cluster can transform the host compound and create a unique compound with a new function. The skin is rich in lipid and skin microbial groups processing this lipid to create a living compound.
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Kowalski found that the human skin sample of a healthy donor performed as a skin cell in the laboratory found that mold bells Malassezia Sympodialis transformed the host geological into antibacterial hydroxy fatty acids. Fatty acids have a variety of functions in cells, but are especially a building block of cell membranes.
Hydroxy fatty acids synthesized by Malassezia Sympodialis are similar to detergents, destroying the membrane of staphylococci and leaking internal contents. KOWALALSKI prevented the colonization of Staphylococcus Aurreus on the skin and ultimately killed bacteria in 15 minutes, Kowalski said.
But mold is not a magical bullet. After sufficient exposure, the pour city bacteria were folded as mold, just as when clinical antibiotics were used excessively.
Researchers found that their genetics found that bacteria evolved mutations in the REL genes to activate bacterial stress reactions. Similar mutations were previously confirmed in patients with staphylococcus aurreus infection.
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The result shows that the interaction with the bacteria and other microorganisms can affect the sensitivity of antibiotics.
Kowalski said, “There is a growing interest in applying microorganisms by treatment, such as adding bacteria to prevent the growth of the pathogen. We know that antibiotics lead to the evolution of resistance, but it is not considered when we think of microorganisms as a treatment. “
The discovery adds a complex layer for drug discovery, but KOWALALSKI is excited about the potential of mold -residential mold as a new source of antibiotics in the future.
It took three years to identify antibacterial fatty acids and tied for interdisciplinary efforts. KOWALALSKI worked with MCMaster University’s chemical microbiologists to track compounds.
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Matthew Barber, an advisor to KOWALALSKI, an associate professor of biology at the University of UO, said, “It was the same as looking for a needle in a pile of hay.
KOWALALSKI is conducting a deeper tracking research that enters the genetic mechanism that causes antibiotic resistance. She also is preparing to launch her laboratory to further investigate the overlooked role of skin microorganisms by breaking up in Barber’s laboratory after focusing on mold.
“Antibiotic -resistant bacterial infection is a major human health threat and in some ways,” said Barber.
(source: By LEILA OKAHATA))
