no way New review Antideporant withdrawal effect-Many people who are closely related to many drug manufacturers written by academia have a risk of underestimating the potential damage to long-term antidepressants by focusing on short-term and industrial funding research.
Serious and sometimes after long -term use, especially after long -term use. weakness Forbidden symptoms, are now recognized by the British government. Public health problem.
One of the main reasons why this problem took decades after the modern antidepressant was launched in the market was that the medical guidelines produced by the ENGLAND ‘s National Health and Care Excel have declared withdrawal effects for years. “Simple and gentle”.
This explanation is based on a study operated by pharmaceutical companies that have taken drugs for 8-12 weeks. As a result, many doctors are later when the patient appears to be a serious and long lasting symptom. I didn’t take them seriously This is because the guideline contradicts the expectation.
Our recent research helps to explain this inconsistency. We have clearly discovered the possibility of someone taking antidepressants and the likelihood of withdrawal and how serious these symptoms are.
We investigated NHS patient And for those who have used antidepressants for more than two years, the withdrawal effect was 10 times higher, and it was 18 times more likely to last longer than those who took the drug within five times the possibility of being serious and the drug within 6 months.
For patients with antidepressants for less than six months, the withdrawal symptoms were mostly minor and short. 3/4 reported no or light symptoms, most of which were less than four weeks.
Only one of these patients could not stop when I wanted. but, For long -term users (2 years or more) and two -thirds reported a serious withdrawal effect of 1/4 of the report. Nearly one -third of the long -term users reported the symptoms that lasted more than three months. One quarter of this patient could not stop antidepressants.
About 2 million people in the UK have been taking more than five years. According to the BBC survey. and In the United States At least 25 million people have taken antidepressants for more than five years. What happens to people in 8-12 weeks is that it’s far from what happens when millions of people stop.
Studying what happens to people after only 8-12 weeks in antidepressants is like testing car safety by colliding with a vehicle on a wall of 5 km/h. Ignores the fact that the actual driver is coming out of 60 km/h.
Do you repeat history?
In this background, the review was just posted. Jamagi psychiatric. Some of the senior authors declare their payments from pharmaceutical companies. If history seems to be repeated, this review is based on a short -term test that is similar to what is used to form an initial treatment guideline (a short -term trial that supports funds in the pharmaceutical industry). The authors concluded that antidepressants do not cause a significant withdrawal effect.
Their main analysis is based on 11 tests that compare the withdrawal of those who have stopped antidepressants. Six of these tests had antidepressants for eight weeks, four for 12 weeks, and one person in 26 weeks.
They have reported slightly more withdrawal symptoms to those who have stopped antidepressants, saying that they are not “clinically significant” withdrawal syndrome. It also suggests that symptoms can be explained by “Nosebo Effect”. Here, people can get worse due to negative expectations.
From our point of view, the results will greatly underestimate the risk of withdrawal to the drug over the years. This review has nothing to do with the period of use of antidepressants and withdrawal symptoms, but long -term research was too small to test this association correctly.
This review will probably underestimate the short -term withdrawal effect by assuming that from our point of view, when people have stopped the placebo, they canceled the withdrawal effect of the antidepressant if they continue to experience the withdrawal. But this is not a valid assumption.
We know that the withdrawal of antidepressants overlaps with side effects and everyday symptoms, but it does not mean that this is the same. This is because people stop the placebo generally causes symptoms such as dizziness and headaches. But it was shown to others Recent reviewAfter stopping the placebo, the symptoms tend to be gentle than they have experienced when the antidepressant is stopped, which can be intense enough. Emergency treatment is required.
Kay ROXBY / ALAMY Stock Photo
Therefore, if you stop the placebo or continue the antidepressant withdrawal from the antidepressant withdrawal, you can underestimate the actual forbidden degree of withdrawal.
In this review, the main analysis showed that the withdrawal symptoms were high. For example, American study More than 60% of those who stopped antidepressants (11 months later) experienced withdrawal symptoms.
The authors suggest that after stopping the antidepressant, depression is probably the rate of depression from those who have stopped the placebo. However, this conclusion is based on limited and unreliable data (ie, depends on the research participants to report such events without systematically evaluating them in five studies).
We hope that critical reporting of a kind of short -term study that first not recognizes the withdrawal effect will not interfere with the slow efforts to help millions of people who can increase the acception and seriously affect the health system.
The author of the new review and the publisher approached for the opinion.
Crystal: The previous version of this article is mentioned as follows: ‘This review does not include some well -designed designed pharmaceutical company studies that discover high proportions of withdrawal symptoms.’ ‘The review does not include some well -designed pharmaceutical company studies that have been found to have high withdrawal symptoms in major analysis.’
