After selecting 20,000 protein coding genes in the human body, Stanford researchers have identified natural molecules such as Semaglutide, the most widely known Semaglutide with brakes on appetite and weight gain.
Since its launch in the United States in 2017, the drug Ozempic has not only helped to lose thousands of weight, but also has a wide range of health boost effects. It showed a promise to fight alcoholism. Knee pain relief due to osteoarthritis; Reduced risk of renal failure and death in some type 2 diabetes patients; The overweight negative impact is in the heart.
But despite all promises, Ozempic offers a variety of side effects. These range from relatively light symptoms such as nausea, diarrhea and dizziness to more serious effects such as cholecular diseases, hypoglycemia and pancreatitis. The drug is even associated with suicide thoughts, and the rare form of blindness, known as “eye stroke,” has increased by seven times.
Therefore, researchers led by a team of Stanford Medicine have confirmed that they can find natural alternatives to Semaglutide, which can provide weight loss benefits while reducing side effects. To do so, they focused on Prohormones, a biologically inert protein molecule when activated when it is activated when it is activated when it is activated when it is activated when it is activated when it is finely called peptide by other protein molecules. Some of these peptides act as hormones in the body.
Researchers have developed an algorithm called peptide prediction variable, analyzing thousands of genes encoding professional hormones, and more specifically, more specifically to be carved by the action of external proteins. As a result, they found a small peptide called BRP, which consisted of 12 amino acids, but increased the action of neuron cells in the brain in the brain. They infer that the development of drugs that work only in the brain will be improved over the entire Ozempic.
Co -author and assistant professor of Katrin SVENSSON pathology said, “The receptors targeted by Semagluide are found in the intestines, pancreas and other tissues as well as the brain.” “This is why Ozempic has a wide range of effects, such as slowing down the movement of food through the digestive tract and lowering blood sugar levels. In contrast, BRP seems to work specifically in the hypothalamus that controls appetite and metabolism.”
Katrin Svensson/Stanford Medicine
The researchers then performed the BRP test on the mouse and mini -pigs, and his system mimics human systems more closely than rodents. They found that one shot from BRP reduced two kinds of food intake up to 50% for the next four hours. In the obesity mouse, when the BRP injects BRP every day for 14 days, the rodents are mainly lost due to fat loss, and have lost an average of 3 grams (about 0.1 ounces) and proved better glucose and insulin resistance.
They also did not see the side effects of BRP after observing the water intake, stool production, movement or anxiety of animals.
Svensson has now co -founded the company with the intention of moving to BRP’s human clinical trials, and her and her team are now studying how to extend the period of the body’s influence. This is easier to take if it is proven to be an effective weight loss solution for humans.
Svensson said, “The lack of effective drugs to treat human obesity has been a problem for decades. “The previous test was not compared with Semaglutide’s appetite and weight loss ability. We want to learn whether it is safe and effective for humans. ”
This study was published in the journal. nature.
source: Stanford University
