Note: This study was updated on March 3, 2025, to correct that ketozenic diet was a low -carb and notice.
For six months, the version of low -carb and high -fat ketozenic diet has resulted in anti -inflammatory conversion of immune cell population among people with stable recurrence discharge multiple sclerosis (RRM) in Phase 2 tests.
This change accompanied the metabolism of immune cells that researchers think they can affect their activation.
The findings are Johns Hopkins University School of Medicine of Michael Kornberg It was held until February 27.
Kornberg said, “It is only additional evidence that the conclusion is that the silver is intermediate and can actually modify the immuno expression (characteristics). “Kornberg said.The six -month ketozenic diet changes the immunity and metabolic environment in multiple sclerosis.. ”
Immune cell activity and MS
All inflammatory immune cell activity plays an important role in causing immune diseases, including multiple sclerosis (MS), and the immune system accidentally attacks the healthy part of the brain and spinal cord.
The metabolic process, including the chemical reaction in which energy is generated, affects the activation of immune cells. Researchers think that the treatment for modifying immune cell metabolism can be helpful to people with immune conditions.
“If you can modify your metabolism with the drug, you can do theoretically intermediate. ”Kornberg said. However, animal studies say that diets can affect the immune response, but “human strict evidence is quite rare.”
The ceremony suggested as this beneficial in Microsoft is a keto -Zenic diet leading to ketone type ketosys and ketosys.
Kornberg is a less limited version of Keto Zenic Diet, which does not require the same carbohydrate restriction, which is modified atkins diet or MAD.
Currently completed Step 2 Study (NCT03718247) In 65 recurrent MS patients with stable diseases aged 12-55, we evaluated the potential advantage of MAD diet for six months.
The result appeared It has greatly improved the physical function, the quality of life, the body configuration, and the reduction of fatigue and depression. The patient also reported the alleviation of several other Microsoft -related symptoms.
The researchers examined blood and immune cells collected from 39 test participants at the start of the study, and aimed to characterize the effects of dietary immune cell function and metabolism in crazy diet six months later.
The composition of the immune cell sub set and the genetic activity profile was substantially changed after six months in the MAD diet and generally showed the transition to the anti -inflammatory profile.
Bone marrow cells, including dendritic cells and monocytes, showed reduced activity of genes associated with the entire inflammatory pathway. They also produced less inflammatory molecules six months later, and the level of such molecules circulating in the blood was reduced.
The diet is also associated with rich changes in various types of T-cells, preferring a low inflammatory population. In particular, by inhibiting the activation of other immune cell types, the regulatory T-cells with anti-inflammatory effects showed signs of increasing richness of diet and more activated.
Although it has not been changed to a diet of B-cells, which is a class of antibody immune cells, which are considered to cause inflammation in Microsoft, these cells have shown a gene activity change that matches the decrease in activation.
Further analysis of blood metabolic products shows that the six -month MAD diet has changed various metabolites related to cell energy production.
The data suggests that the metabolic path immunocytes used to produce energy have been changed. Prior to the diet, the cells seemed to prefer to break down sugar for energy (sugar decomposition), but after that, it was preferred using fat molecules (fatty acid oxidation).
This has been proven by the reduced level of glut1, a molecule involved in transporting sugar with cells after six months.
Kornberg said that this changed path is “a path that is particularly related to the revitalization of immune cells.”
It is not yet known whether such immune cell changes affect the clinical results of Microsoft patients, and it is not exactly clear whether crazy mechanisms can affect immune function.
Kornberg said the patient’s long -term safety should be established.
This study is Doris Duke Foundation and Mayer Foundation.
