Aging, lifestyle and cell health

It was tentatively accepted

By 2050, the world’s population of 65 years of age or older exceeds 1.6 billion, consisting of 1 out of 11 to 6 in 2019 (1). The expectation of expectations has increased, but the health range has not maintained the speed, so many people have experienced getting worse for 10 years later. Population aging deepens the economic impacts, including manpower contracts, tax revenues, increase in demand for government support programs, increase in medical costs, and government budgets. These factors accelerate functional decline as a whole and increase the risk of age -related diseases. To understand aging, it is necessary to analyze the changes by system and interaction between the system. For example, the immune system suffers from immune aging, inflammation and disorders and weakens defense against infection (2). In the cardiovascular system, vascular aging increases the risk of cardiovascular disease (CVD) by damaging endothelial function and vascular expansion (3). Metabolic dysfunction, including nutrient detection destruction, chronic inflammation and oxidation stress, increases cardiovascular risk by exacerbating atherosclerosis and arterial rigidity. Parallel degenerative changes in the neurot and musculoskeletal system contribute to cognitive reduction and SARCOPENIA (4). In addition, aging acceleration of an organ affects other organs through shared paths associated with inflammation, oxidation stress and hormone regulation, causing companionship. This concept of multi -period aging emphasizes the complexity of age -related diseases. Diet is known to have a big impact on the promotion of health and disease. Although research has traditionally focused on large amounts of nutrients, small amounts of nutrients and trace elements, food metabolism and bioactive compounds are recognized as important for aging. Usda National Nutrient Database catalogs 7,793 foods and 150 components, which are part of 26,000 known food -derived biochemicals (5). In addition, microorganisms produce over 44,000 compounds, which have biological functions (5). This special study topic is to target the effects of bioactive compounds on cell health and lifespan, especially microbial group related and inflammatory mechanisms that affect certain biological functions. The manuscript included in this collection shows the effects of new evidence and aging of nutritional biological activity. Dysbiosis contributes to the negative impact on barrier dysfunction, harmful metabolites and muscles and neurological tissues. Jang microorganisms also affect muscles and cognitive functions by adjusting immune response, neurotransmitter and metabolites. Age -related muscle loss and cognitive reduction are associated with inflammation, oxidation stress, and microbial composition, and induces interest in prevention and treatment strategies. CAI et al. The 12 -week oral administration of Lacticaseibacillus Paracasei (LC86) has been shown to alleviate cognitive reduction in mouse 8 (samp8) mice due to its invasion and aging (CAI et al). Treatment improves health range, reduces aging phenotype, increases muscle glycogen reserves, improves muscle strength and cognitive performance. The LC86 also promoted the level of neurotransmitter, systemic inflammation, improved liver antioxidant defense, and beneficial intestinal microorganisms. Triptophan, an essential amino acid, acts as a precursor for metabolites and neurotransmitters while regulating inflammation. Nutrition -related tryptophan depletion increases the vulnerability of the patient. Ritz et al. In order to evaluate the prognosis importance of Triptopan Pathway Metabolism, we analyzed the clinical trial sub -set. Nutrition patients have a low level of tryptophan and are associated with severity of disease, but have no nutritional intake or risk scores (NRS 2002) (Ritz et al). Low tryptophan, Kinu Lenin and serotonin were highly mortgage rates for 30 and 180 days. Despite the increase in the risk of death, nutrition support was less effective for these patients. The study concluded that Triptopan and its metabolites provide independent prognosis value in the risk individual (Ritz et al). The muscle mass is stable up to 40 years old, and after 65-70, the decrease has accelerated. Aging muscles also indicate protein expression, mitochondrial abnormalities, ion control disorders and changes in stress response. The EGGSHELL membrane (ESM) is rich in bioactive compounds, including N-glycans, known to promote joint health, wound healing and skin perfection in protein, glycosa minoglycan (GAG) and clinical and trial studies. ESM hydrolysis can maintain anti -inflammatory properties after digestion and relieve joint pain and rigidity. ESM powder has proved its efficacy in reducing intestinal inflammation and microorganisms while improving skeletal muscle mass, but there is also a molecular effect on the muscles of Ronning et al. Specifically, recent discovery indicates that aging features, including the loss of muscle fiber, modified fiber composition, and muscle atrophy, and regeneration, which are relaxed (Ronning et al). It also promoted young muscle phenomena at the protein level. ESM consumption has increased the total diversity of intestinal microorganisms, and has increased inflammatory markers in compositions and human studies (Roning et al). Such discovery is a potential functionality that ESM can oppose skeletal muscles aging through immunomodulation and microbial interaction, but further research is required, but in comprehensive review, Jacquier et al. The effects of plant nutrients for cells, organs and functional aging parameters were evaluated using a framework for vitality, essential capacity and ability expressed in the elderly. This review proposes a paradigm shift that includes specific plant nutrients in preventive nutrients based on the ability to control the characteristics of certain aging. The bottom line is that if it affects several organ systems, the process increases the risk of physiological reduction and disease. Although the life expectancy has been improved, it is still difficult to expand the health range. The new study emphasizes the role of nutrition, intestinal microbial guns and bioactive compounds and how to control aging by preserving functional health. Dietary mediation and functional foods can provide innovative solutions to promote healthy aging and reduce age -related diseases. However, further studies are required to convert these results to practical applications to expand their health range and improve their quality of life.