Eight healthy children born using 3 -person IVF technology
As a result of long waiting for the three -person IVF technology, the mitochondrial donation suggests that the baby can not inherit the disease caused by mutant mitochondria.
Maurizio de angelis/science source
Eight children in England lives a healthy life. Controversial reproductive procedure Researchers report today that the researchers are aiming to prevent them from inheriting fatal state from their mothers today.
Infants are designed through donation of mitochondrials, Transfer the nucleus of the fertilized egg It is defective in the donor al -cells with a healthy mitochondria with mitochondria. It aims to prevent a baby from inheriting harmful mutations in her mother’s mitochondrial DNA, which can cause diseases affecting power background tissues such as hearts, brains and muscles.
Dietrich Egli, a stem cell scientist at the University of Columbia, New York, said, “This is a breakthrough study in the prevention of mitochondrial diseases.
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The procedure has been dubbed 3 people Test Crystal (IVF)This is because the generated children carry nuclear DNA from a biological mother and father, along with the mitochondrial DNA from the separate egg donor.
Rare procedure
uk It has become the world’s first country to explicitly regulate mitochondrial donation. After more than 10 years of research, discussion and discussion in 2015. Only the New Castle Fertility Center, a British clinic, received a license for the fertility regulator, human fertilization and embryos (HFEA).
Latest research- New England Journal -This is the first detailed report of the Newcastle Team’s efforts. In 2023 guardian The newspaper has been released Up to five British children were born using mitochondrial donation.. But there were few details about other questions surrounding the effects of the health and technology of children.
22 women with mitochondria, which caused the disease, led to eight births (including a pair of pairs) and one ongoing pregnancy through the mitochondrial donation process of nuclear warfare and one -time pregnancy.
Four girls and four boys -all -children are born healthy and are developing normally. The oldest child is now 2 years old or older than 5 months old. Five children had no health problems at all, one of which had been successfully treated with experienced muscle fools, and other children were successfully treated with high levels of fat and heart peeling disorders, and one -third was heated by urinary tract infections.
Robert McFarland, a pediatrician of Newcastle University, said, “We are carefully optimistic about these results.” I know. “
There was a donation of Mito Code Lee It has been done in several other countries Without obvious regulations -as a treatment of reproductive power, at least one to prevent mitochondrial disease.
Pathogenic mitochondria
When shuttle of the fertilized eggs as a donor cell cell that empty the nuclear DNA, some of the pathogenic mitochondria can be carried with the nucleus. As the embryos develop, the ratio of pathogenic mitochondria can be amplified to a high level that causes disease.
The Herbert team found five children and found a sign of or very low of pathogenic mitochondria in the mother’s eggs. In the other three, the proportion of pathogenic mitochondria ranged from 5% to 16% of the total. Herbert said in a briefing, “This is higher than we expected.”
Paula Amato, a reproductive internal secretary of Portland’s Oregon Health Sciences, said that this level would not be high enough to cause disease. However, the researchers added only cells collected from blood or urine at birth, and added that the level of mutant mitochondria is higher in other tissues and organs, which can change over time.
Two of the three children with detected pathogenic mitochondria are women and there is a risk of transmitting these mutations to their children. The fetal genetic test can block it, EGLI and others say.
Dagan Wells, a reproductive geneticist at the University of Oxford, said that his team carried mitochondria from seven children who were designed through mitochondrial donation in Greece. “This suggests that we should pay attention to this, and it is not necessarily avoiding disease transmission,” he says.
This article was reproduced with permission and did First publication July 16, 2025.
