UC Santa Barbara is a campus biotech -off integrated life sciences, Harvard, MIT, Princeton, and genome company Illumina Ventures to help you with the use of light to help you more effectively use the light to investigate the functions of living tissues. Find the compound. Using an optical platform developed in UCSB’s synthetic biologist Max Wilson laboratory, they have already discovered dozens of molecules that can act as promising development candidates in the Fire virus space, especially two chemical scapolds.
“We have been tested in Zika.” And they worked. RSV: They worked. Herpes: They worked. And they worked almost with cutting -edge treatment, but were not completely optimized. So it’s very promising. “
Their research Journal cell.
Integrated stress reaction
The integrated stress reaction (ISR) is a cell mechanism that we are grateful for helping us adapt and restore our physiological stress to us. From the virus to the cancer, from nutritional deficiency to age -related nerve degeneration, the ISR sets a motion complex process for promoting the death of the programming to survive, restore, degraded, and remove damaged cells.
Wilson said, “This is a very important signal network. In fact, ISR acts like a herb to encrypt a particular protein or cause changes in gene expression to take a stress signal and activate the response as needed.The scientists know for a long time of the potential of this strong mechanism and biotechnology, so in various insults in various insults. It helps to recover, but it is difficult to use the power of ISR.
“The normal environmental stress in cells activates multiple paths at the same time,” Wilson said. In addition, in order to generate such a specific reaction, the cell must be stressed, but it is difficult to determine whether the reaction is due to the damage from the ISR path or due to the damage of the cells or the other influence of cell repair or failure. In addition, molecules that activate the appropriate ISR paths must be therapeutically effective in the cell itself.
