Scientists once disbanded the 1958 hypothesis of vitamin B1 or thiamine, but there is little possibility. The idea is that this vitamin, essential for basic metabolism, can turn into a very reactive intermediate in a particular biochemical process.
The researchers now show that the intuition is correct. Vincent Lavallo At the University of California, RiversideUCR) Investigate that vitamin B1 can form a reactive species called carbene even around water.
Understanding vitamins B1 and Carbenes
Cabens There are six atoms of carbon atoms. They are known to have a high reactivity and often disappear after formation.
In general, water that almost interrupted these molecules was not considered a friendly environment for them.
Lavallo said, “This is the first time someone was able to observe a stable Carben in the water, but people thought this was crazy, but Breslow was right.
Thiamine is the core Basic work In the body, the destruction of sugar for energy.
Why are you so much doubted so long?
Carbenes reacts so quickly that it was considered too unstable for water. Even before scientists have the opportunity to study, even moisture in the air can destroy them.
Most of the initial attempts to observe Karben in the water ended in failure. They have strengthened their belief that they disappear or break down into other molecules and cannot last in the water -based system.
The skepticism ran deeply. Researchers preferred to work with these molecules in an environment without dry oxygen using special laboratory settings.
This not only kept the idea of observing them in the water, but also sounded like a science fiction novel.
A fresh approach working in water
Carben in the water was seen impossible This is because water usually attacks such an electromagnetic carbon center.
“We did not pursue historical theories, but to explore their chemistry, but our research was confirmed exactly what Breslow proposed a few years ago.” Dr. SupplementUCLA’s post -doctoral researcher.
He and his colleagues developed a special chemical cover (molecular shield) to prevent Karben from contacting water. This shield has prevented immediate breakdown.
1958 Theory was found to be true
chemist Ronald Bre Slow Thiamine suggested that it could be transformed into a carben during a particular body reaction.
No one can prove it. The new result shows that under the correct conditions, the carben of the vitamin B1 is stable enough to observe high -quality tools such as nuclear magnetic resonance.
Researchers say that this stability helps to explain how important changes occur in living cells. Their protection strategy shows that the body can form a short -term carben intermediate during everyday metabolism.
Eco -friendly B1 manufacturing
These Karben can act as ligands in metal -based catalysts, which are widely used to produce many substances. Because the dependence on harmful solvents decreases, the Carbens in the water can open the way to a cleaner process.
Raviprolu said, “Water is an ideal solvent-rich, non-toxic and environmentally friendly.
This catalyst can transform the drug and everyday materials. Some industrial reactions are famous for producing chemical waste.
By utilizing aqueous technology, hope is to reduce costs and avoid safety issues related to flammable liquids.
In the laboratory, we imitate the chemistry of life
Living cells depend on complex water -based reactions to maintain the body. Most of these reactions include fast and reactive intermediates that are difficult to detect or replicate in the laboratory.
The fact that Lavallo’s team can stabilize molecules that mimic this behavior can help researchers to reproduce cell chemistry more accurately.
It means a better grasp of how enzymes work, and perhaps a new way to recover or re -program the functions in medicine.
Carben is often studied on the ability to imitate some of the enzyme action. Now scientists can make them act in a lot of water, so you can start looking for a way to control it for a specific biological work.
This eventually can change the way we design drugs or substances inspired by enzymes that are only reacted only under the same conditions we find in human cells.
Next step using vitamin B1
Proving Carben’s intermediate body can survive in the water to solve the mystery of the potential of vitamin B1. It also raises new questions about other fierce molecules that can exist in a living system.
Lavallo and his team hope that similar methods can reveal more hidden players related to major biological reactions.
Raviprolu said, “If we continue to invest in science, it may seem impossible tomorrow.
This result is suggested that no matter how far you are without thorough studies, no one should ignore the theory.
This study has been published Science development.
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