Popular weight loss drugs, such as ozempic, can help reverse the low testosterone levels of men with obesity or type 2 diabetes. New research.
You can based on previous studies that show weight loss surgery or lifestyle changes. Increase testosterone levels SSM Health St. in the body Researchers at Louis University Hospital analyzed 110 male electronic health records with obesity or type 2 diabetes to monitor the changes in hormones, taking GLP-1 receptors such as semgalutide and tirzepatide.
They measured testosterone levels for 18 months before and treatment of drugs. About half of men had low refined testosterone at the start of the study and reached normal level after treatment. The average age of the participants was 54 years old.
SSM Health St. Dr. Shellsea Portillo Canales, a endocrine scholar of Louis University Hospital, said in an email, “The increase we observed is more humble than the testosterone replacement therapy.” As insulin resistance improves, it can reflect the body that restores normal hormone production. ”
The study already emphasizes the need for men using testosterone therapy to closely monitor the level after starting weight loss drugs, Portillo said.
In some cases, men may need to lower or discontinue testosterone supplements. Especially if testosterone is normalized in weight loss drugs.
There are limitations in new research. The results do not prove that the increase in testosterone was caused by the drug semagluide or Tir fade. This was later fragrant research, and researchers analyzed existing medical records over time rather than randomly conducted clinical trials. And after the men stopped the drug, they did not check the testosterone levels.
Portillo said, “If you recover your weight, testosterone levels can be reduced again.
The findings were presented this Monday at Endo 2025, an annual meeting of the end -secretion associations held in San Francisco this Monday. Researchers plan to submit to a medical journal for fellow review.
Dr. Susan Spratt, a medical professor at Duke University School of Medicine, said that many men are excessively processed when they are low in terms of low levels. “It would be better to naturally increase testosterone than to treat obesity or diabetes and prescribe testosterone.” Spratt, not part of the study.
According to Mayo Clinic, some risks of testosterone therapy include sleep apnea, acne worsening, prostate or chest enlargement, increased growth of prostate cancers, reducing the number of sperm, and increasing the risk of coagulation.
This study shows the dual benefits of men’s weight loss drugs. Dr. Fatima Cody Stanford was spoken by Massachusetts General Hospital and Harvard College of Medicine.
“The result of this study emphasizes an important intersection between metabolic health and hormonal balance.” This double benefit emphasizes the potential of this drug, which can improve overall health results including reproductive health in this population. ”
The normal testosterone level is 300 ~ 1,000 nanomes per decey liter.
Testosterone tends to gradually decrease as you age from your late 30s and early 40s. Portillo said that at the age of 75, the average male testosterone level fell to about 65%of the average level seen in young people.
Portillo said, “Improving testosterone can improve your quality of life and reduce your health risks related to low levels.
SPRATT said it is important to distinguish between low testosterone levels that increase to normal and normal testosterone levels maintained in the normal range.
Experts say that testosterone levels are the most important because the lower testosterone can lower bone density, increase the risk of fractures (increases the risk of fractures), and reduce muscle mass, lower hemoglobin (red blood cells) and reduce sexual desire, experts say.
Spratt said, “But treating low testosterone without known cause is controversial, and has increased over the last decade due to consumer marketing direct marketing.
Researchers included only men in research because weight loss drugs did not expect women to increase testosterone levels.
Portillo said, “In general, we do not regularly measure the testosterone of women if there is no sign of hormonal imbalances such as excessive face hair, irregular times, infertility or masculinity.
In this case, testosterone tests can help to diagnose a condition such as polycystic ovary syndrome, PCOS, adrenal disorders or rare tumors.
Some studies of women with PCOS, which are in a state of increasing testosterone levels, suggest that GLP-1 therapy can help slightly lower testosterone by improving metabolism and reducing insulin resistance.
Certain state is well known to reduce testosterone in men, especially those around the abdomen, especially in the abdomen, which interferes with hormonal signals with testicles in the brain, experts say.
Portillo said, “Fortunately, lifestyle changes and drugs can turn it over in many cases.
