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Rochester General Hospital, Texas Southwestern Medical Center and AGA Khan University have reported that applying new cardiovascular risk equations to rapidly reduce the number of candidates in aspirin to prevent heart disease.
Heart scholars and public health experts measure the balance between aspirin’s potential benefits and the known risks of major bleeding in lowering cardiovascular events. The guidelines for the US Prevention Service Task Force are recommended to consider aspirin of adults aged 40 to 59, which are estimated to have more than 10 years of cardiovascular risks of 10 years or more than 10 years.
The researchers have developed a risk of predictive of cardiovascular disease events (prevention) equations, which created a lower and better correction risk estimation than pooled cohort equations, but the effect of the use of aspirin was not investigated.
In a study letter, “Using equations to guide the use of aspirin to prevent the primary prevention of cardiovascular disease” Post ~ ZaemagiResearchers analyzed whether preventive applications change the qualifications of aspirin.
The team represents about 59.4 million people aged 40-59 from 3,158 participants from 2015 to 2020 in the National Health and Nutrition Examination Survey.
Excluding severe kidney disease, urine high urine bumin, low platelet, cancer, heart failure or certain drugs (steroids, anti -lineages, anticoagulants) were excluded.
Using pooled cohort equations and prevention, we calculated the 10 -year cardiovascular risk to evaluate the qualification. Aspirin is defined as a danger of more than 10%. The researchers also reported the ratio of adults taking aspirin, even if the calculated risk fell below this critical price.
According to the results, 8.3%of middle -aged adults, that is, about 4.9 million people, are qualified as aspirin under the fully cohort equation. Only 1.2%or about 700,000 people qualified according to prevention. 85.9%of the gathering cohort standards did not meet the prevention threshold. Nearly 97%of the 7.6 million adults who reported the use of aspirin for prevention did not meet REAST’s qualifications.
The author concluded that it would raise an urgent question about whether the adoption of prevention should use the same 10% cutoff, which is applied to the spherical calculator. In order to set a precautionary threshold, a dedicated modeling study may be required to determine the advantage of aspirin.
The researchers reported that most adults report their own use of aspirin during the study period, and they did not meet the standards through the calculator, and the practical opportunity to stop treatment where there was little profit.
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Additional information:
Ahmed Sayed, etc., uses prevention equations to guide the use of aspirin to prevent cardiovascular disease. Zaemagi (2025). Doi: 10.1001/jamainternMed.2025.5049
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recallMost of the Aspirin use of middle -aged adults can be unnecessary depending on the new evaluation (2025, October 3). October 4, 2025
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