GLP-1 drugs can reduce inflammation so that the brain can be kept sharp and sharp.
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Diabetes and weight loss treatment, such as Ozempic and Wegovy, known as GLP-1 agents, can significantly reduce the risk of dementia on all types of dementia, according to meta-analysis of 26 clinical trials with more than 160,000 participants.
Treatments including drugs such as Semaglutide, Liraglutide, and Exenatide were associated with the risk of previously reduced dementia, but it was based on observation studies to look at health records.
now, Catriona Reddin Ireland’s University of Golway and colleagues combined randomly test results with a variety of GLP-1 drugs for those who had a type 2 diabetes that were not diagnosed with dementia or cognitive impairment tested for the process. They have shown that taking these drugs greatly reduces the risk of dementia or cognitive impairment during the at least six months of tracking.
“The gold standard is a large random test for answering this question, but this definitely adds other evidence (past research).” Ziyad Al-ALY At the University of Washington University in Louis, Missouri, who did not participate in this study.
Diabetes DementiaTherefore, only control of blood sugar can lead to this protection effect. For example, A study By ~ Jingchuan guo Florida University and colleagues suggest that the type of diabetes drug, called SGLT2 inhibitor, which removes excessive glucose and reduces blood sugar levels, can reduce the risk of Alzheimer’s disease or related dementia according to people’s health records.
But in the placebo-controlled analysis of Reddin and her team, SGLT2 inhibitors were not related to the reduction of dementia risks, suggesting that the protection of GLP-1 drugs exceeds blood sugar control.
The exact mechanism is unclear, but the drug is associated with inflammation reduction. Nerve inflammation It is becoming more and more recognized as a cause of dementia. By reducing chronic inflammation, they can do it BrainReddin says.
GLP-1 drugs can also be protected Cardiovascular problemsuch Plaque In arterial arteries HypertensionOtherwise, it can cause dementia.
Al-ALY said, “All roads seem to lead to Rome, we can see in many observation studies, and now we can see that these drugs have this (anti-example) effect in analysis of placebo control studies.
Al-ALY emphasizes that we are not yet where people are prescribed GLP-1 drugs to reduce the risk of dementia. However, he can also consider the doctor to provide other glucose lowered drugs to those with a type 2 diabetes that reduces other glucose, for example, there is an increasing risk of decreasing whether there is a family history of the state. “This study will increase the doctor’s tendency to prescribe these drugs,” he says.
REDDIN pointed out that at least six months of tracking period was relatively short and “a large -scale test should be conducted to study the impact of glucose deterioration on dementia and cognitive reduction.” As a treatment for the early Alzheimer’s disease, two clinical trials that investigate the three retails are expected to conclude this year.
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