According to researchers at the University of New York, more than 24 bacteria and fungi are found in their mouths that may be associated with pancreatic cancer (PC) risks. Posted data Zama OncologyThe oral microbial gun suggests that it can serve as a non -invasive biomarker that can be easily accessible for PC risk assessment.1
Pancreatic cancer
In 2025, 67,440 new PCs were diagnosed, representing 3.3%of all cancer diagnosis and 8.4%of all cancer deaths. The prognosis of the PC is relatively poor, and the five -year survival rate is 13.3%, which falls to 3%for patients with metastasis. Due to more ambiguous symptoms, it is difficult to treat. PC patients are generally age and about 72 years old.2
Researchers wrote, “There is little known how to prevent this cancer.” “Smoking, obesity, pancreatitis and genetics are known for risk factors, but these factors describe less than 30% of all pancreatic cancer. To reduce the burden of pancreatic cancer, you need to improve scientific knowledge of the specific causes of this disease and provide guidelines for preventive measures.”1
Treatment for PCs is stagnant, and even modern therapy cannot penetrate silkworms of collagen fibers that protect tumors in the immune system or treatment of the body. Immunotherapy is not often optional. Unlike other cancers, PC cells are low in immune origin and are less likely to produce an immune response. These therapies are generally suitable for patients with a large number of genetic or high tumor mutations.3
Evidence of the association of oral microbial guns and PC risks. However, bacteria 16S ampoule recon sequencing and small post-controlled case-control study is greatly limited.1
research
Currently, the researcher’s discovery can provide an opportunity to identify and solve PC risks before the disease is later proceeded. They conducted cohort studies including two dynamic cohorts of individuals: American cancer association cancer prevention studies -II nutrition cohort and prostate, lungs, colon and ovarian cancer screening test.1
Participants without cancer were selected using a 1: 1 frequency consistent based on the time after collecting the cohort, 5 -year -old age group, gender, race and ethnicity, and the time after the collection of shoes. Data collection occurred from August 2023 to September 2024 and analyzed from August 2023 to January 2025. A total of 890 participants were included in the analysis, 474 (53.3%) of them were men, and the average age (SD) was 67.2 (7.5).1
The researchers use the entire genome shotgun sequencing and internal transcription spacer (ITS) sequencing to profile the oral bacteria and fungal microorganisms. The connection between the PC and the periodontal pathogen was evaluated using the Logistic Regression and focused on the red and orange composite species.1:
- Red -colored species
- Treponema denticola
- Porphyromonas gingivalis
- Tannerella Forsythia
- Orange complex species
- Fusobacterium nucleatum
- F. Periodist
- Prevetella intermediate body
- A. nigressens
- Parvimonas Micra
- Eubacterium nodatum
- Campylobacter Showae
- C. Gracilis
The analysis of the composition of microorganisms with bias-BC2 was used to evaluate the microbial cluster-overall association. The microbial risk score (MRS) of the PC comes from bacteria and fungal species associated with risk increase.1
result
Of the 122,000 oral samples collected from the patient, 445 people developed a PC during the 8.8 years of intermediate tracking (IQR, 4.9–13.4) and consisted of 445 control groups.1
The analysis of the oral microbial cluster showed some important connections. 3 periodontal pathogens-Porphyromonas gingivalis (Or 1.27, 95% CI 1.03-1.57)Eubacterium nodatum (Or 1.42, 95% CI 1.14-1.76),,, and Parvimonas Micra (Or 1.36, 95% CI 1.09-1.70)–It was related to the increase in the risk of the PC. six Actinobacteria3 bacteroidets, 3 Firmicutes1 Fuso bacteria The bell was also related to the increase in risk.1,4
When the oral bacteria were tested more extensively, the eight bacterial species were associated with six periodontal disease pathogens and three reductions of risks. Proteo bacteria Bell, 2 BACTEROIDETES Bell, 2 Actinobacteria bell. The decrease in risks was also consistent with oral mold. Candida Albikanes (0.77x, 95% CI 0.62-0.96) and Globosa Malassezia (0.84x, 95% CI 0.73-0.98).1,4
The fungal microbial cluster also showed a relevant connection. inside Candida It was identified as a risk factor of pancreatic cancer and further emphasized the role of oral mold in cancer sensitivity (1.58 times, 95% CI 1.05-2.38). Here is included Candida tropical (1.43 times, 95% CI 1.00-2.03) Candida (1.34x, 95% CI 1.05-1.70). The history of use of tobacco has increased this association, while BMI, alcohol use and diabetes did not.1,4
Regarding the MRS, researchers have a high probability of a high MRS value, and each one standard deviation is more than three times the risk.1
“Our evidence suggests clustering trends of periodontal pathogens and newly identified major oral bacterial species. This can cause de Novo carcinogenic mutations in pancreatic cells. This tends to show that low -risk species tend not to indicate such modules, and thus supports the proposal that metabolic profiles of oral microorganisms may be associated with pancreas.1
