Researchers at Integrated Biosciences have developed a new platform that enables the control of milliseconds and microns for biological systems that are easy to deal with, and unlocked new treatment opportunities for age -related diseases.
This platform combines optical, chemistry and AI to find a small molecule treatment for age -related diseases.
New colleague review publication Apply to the integrated stress response to show the function of the platform. (ISR), major aging and disease -related signal paths involved in nerve degeneration, cancer and virus infection.
The benefits of ISR to reduce the pathology of age -related diseases
Scientists use optical control to selectively activate ISR, which allows for some ISR-target compounds that make stress sensitive to POP toys without inducing cell toxicity through various cell types and highlights.
The lead compounds identified in the study showed a wide spectrum antiviral activity in the test, and one compound significantly reduced the disease pathology and viruses in the mouse model of the eyeball herpes virus age -related infection.
A strong new approach to drug discovery
The new platform allows the accurate and dynamic control of biological goals and processes to unlock a strong new approach to drug discovery.
By integrating programmable and optical response domains with automated high -handling screens, the platform interrogates biological systems at millisecondimal and micron -scale spatial resolutions.
With this unique module system, researchers can solve the compound effect in real time over a variety of goals, cell types and age -related diseases, providing precise and control of conventional screening technologies.
Dr. Maxwell Wilson, co -founder and chief scientific officer of Integrated Biosciences, said, “Synthetic biology tools such as optics can accurately adjust the complex cell processes that cannot be done by traditional drug screening.
“Through our platform, we can activate certain objects and paths with light to create clean and interpretable reading values and create a fixed compound discovery with unprecedented behavioral mechanisms that have not been previously accessible.”
Main advantage of traditional screening tools
Unlike conventional and pharmacological tools, the platform enables optional and route activation without route or systemic confusion effect, allowing them to create a clean and unique wide route specified data set.
This is especially important for phenotype screening and AI drive discovery of large bottlenecks in extracting insights with meaningful insights.
It also provides a general strategy for discovering small molecules that are complex and traditionally difficult for drugs, including age -related diseases.
Since the system is module and adjustable, it is possible to quickly adapt to exploring a wide range of biological processes with the main benefits of the traditional screening tool, which is the main advantage of the field.
Wilson concluded: “This is just the first demonstration of what our optical platform can do.
“Synthetic biology provides the controls needed to build a more accurate disease -related discovery system. Our goal is to bring this level of precision to other paths where existing tools have failed.”
