Foods, which even one of the hundreds of people, have the least amount of gluten, can cause wounds and serious risks.
The domino effect of immunological response is Gene rootMany contributions are also related, making it difficult to map the chain of the exact event that causes cavity disease.
Use of Trans Zenic Mouse, an international team led by scientists at McMaster University, Canada We have confirmed the important role The same cells that make up the lining of the intestine postpone the main stepping stones that can lead to new treatments.
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CELIAC Disease is an immune disorder caused by the presence of a structural protein group known as gluten in the intestine.
In fact, eat anything Most baked foods, bread and pasta made of wheat, barley or rye. People There is a risk of temporary symptoms such as bloating, pain, diarrhea, constipation, sometimes backflow and vomiting.
The only way to avoid the current symptoms is to avoid foods that cause symptoms. Immune attack triggered by gluten can in the long run It damages the billy of a small intestine. These Small structure It helps to absorb nutrients from food by increasing the internal surface area of the barrier.
A person with a body disease -especially if not being treated -in the face of serious health risks Development of colon rectal cancer and Cardiovascular disease. This disease is related to numerous conditions anemia,,, Osteoporosis,,, Growth delay,,, Reproductionand Nervous system.
“The only way we can cure body disease today is to completely remove gluten from the diet.” Say Elena Verdu.
“This is difficult to do and experts agree that gluten -free diet is not enough.”
About 90 %of people diagnosed in a state -DQ2.5. Most of the remaining 10 % have a similar protein called HLA-DQ8.
Like other types of ‘HLA’ (or Human white blood cell antigen) Protein, protein is a fallen invader piece A Class of immune cellsOther defensive organizations warn of warnings.
In certain cases of HLA-DQ2.5 and HLA-DQ8, the protein has a lump of gluten peptide, which is resistant to digestion, and instructs the murdered T cells to hunt.
Unfortunately, these instructions are not most obvious in distinguishing substances similar to the threat of our body, so people with genes are in danger of immune conditions.
Not all However, a person who expresses HLA-DQ2.5 or HLA-DQ8 will have immune disorders such as celiac diseases.
In order to happen, the torn gluten pieces must first move across the barrier. Enzyme It combines with the peptide so that it can be recognized more.
The cells of the barrier help to release this transport enzyme to the intestine, which clearly plays an important role in the early stages of the disease.
They are also known Express the family’s family If HLA-DQ2.5 and HLA-DQ8 belong, this is generally regulated by the inflammatory reaction in the intestine.
What is not clear is how this weapon is actually actually functioning within the pathology itself.
In order to focus on this important link in the chain, the research team has reaffirmed the expression of major immune complexes in human genes and mice of people with treated and untreated body disease and HLA-DQ2.5.
Then, using mouse intestinal cells, we created a functional alive model of the intestine called Oganide, and used not only inflammatory triggers as well as inflammatory triggers in close proximity to the expression of immune protein.
“This allows us to narrow the specific causes and results and to prove exactly how the reaction occurs.” Say MCMASTERS Biosynthesis Engineer tohid Didar.
From this, it is clear that cells that surround the intestines are not passive half of the incidental damage due to wrong efforts to remove gluten’s body. They were the main formulations and presented the mash up of gluten sculptures decomposed by the intestinal bacteria and to carry the enzyme with gluten-specific immune cells.
Knowing the improvement of the type of relevant organization and the existence of inflammatory microorganisms, the researchers provide a new goal for the future treatment so that millions of people around the world can enjoy two risks full of gluten.
This study has been published Camouflage.
The previous version of this article was published in August 2024.
